Introduction to Allergy and Immunology ICD 10 Codes
Allergy and immunology practices serve a critical role in diagnosing and managing hypersensitivities, immune dysregulation, autoimmune diseases, and conditions related to food, environmental, and medication allergens. Precise ICD-10 coding for allergy and immunology practices is essential for accurate documentation, clinical care coordination, prior authorization, and insurance reimbursement.
Whether you’re evaluating patients for seasonal rhinitis, food intolerance, drug allergies, or autoimmune deficiencies, this ICD-10 guide for allergy and immunology will support efficient coding and improve administrative workflows. For practices using DocVilla, this resource becomes even more powerful. DocVilla’s cloud-based EHR supports comprehensive ICD-10 libraries for allergy and immunology, customizable allergy templates, automated encounter documentation, electronic prescribing, and diagnostic test integration.
This compilation of common ICD-10 codes for allergy and immunology spans allergy testing, anaphylaxis, immune disorders, autoimmune conditions, chronic urticaria, mast cell disorders, immunoglobulin deficiencies, and more.
Food Allergies and Intolerances
- Z91.010 — Peanut allergy
- Z91.011 — Milk allergy
- Z91.012 — Egg allergy
- Z91.013 — Seafood allergy
- Z91.014 — Other food allergy
- T78.01XA — Anaphylactic reaction due to peanuts, initial encounter
- T78.02XA — Anaphylactic reaction due to shellfish, initial encounter
- T78.04XA — Anaphylactic reaction due to tree nuts/seeds, initial
- T78.05XA — Anaphylactic reaction due to eggs
- T78.06XA — Anaphylactic reaction due to milk
- T78.07XA — Anaphylactic reaction due to fruits and vegetables
Environmental and Seasonal Allergies
- J30.1 — Allergic rhinitis due to pollen
- J30.2 — Other seasonal allergic rhinitis
- J30.81 — Allergic rhinitis due to animal (cat, dog)
- J30.89 — Other allergic rhinitis
- J30.9 — Allergic rhinitis, unspecified
- T78.40XA — Allergy, unspecified, initial encounter
- Z91.09 — Other allergy, not elsewhere classified
- J31.0 — Chronic rhinitis
- Z91.040 — Allergy to animals (excluding food)
- Z77.09 — Contact with and exposure to environmental pollution and allergens
Drug and Medication Allergies
- Z88.0 — Allergy status to penicillin
- Z88.1 — Allergy status to other antibiotics
- Z88.2 — Allergy to sulfonamides
- Z88.3 — Allergy to other anti-infective agents
- Z88.6 — Allergy to analgesic agent
- Z88.8 — Allergy to other drugs
- T78.2XXA — Anaphylactic shock, unspecified, initial
- T88.6XXA — Anaphylactic reaction due to adverse effect of correct drug
- T50.901A — Poisoning by unspecified drug or medicament, accidental
- Z91.120 — Patient’s intentional underdosing due to adverse effect
Skin and Contact Allergies
- L23.7 — Allergic contact dermatitis due to plants (except food)
- L23.0 — Allergic contact dermatitis due to metals
- L23.5 — Allergic contact dermatitis due to drugs and medicaments
- L23.8 — Allergic contact dermatitis due to other agents
- L23.9 — Allergic contact dermatitis, unspecified
- L50.9 — Urticaria, unspecified
- L50.8 — Other urticaria
- L27.0 — Generalized skin eruption due to drugs
- L27.2 — Dermatitis due to ingested food
- L20.9 — Atopic dermatitis, unspecified
Anaphylaxis and Hypersensitivity Reactions
- T78.0XXA — Anaphylactic reaction due to food, unspecified
- T78.1XXA — Other adverse food reactions, not elsewhere classified
- T78.2XXA — Anaphylactic shock, unspecified
- T78.3XXA — Angioneurotic edema
- T78.4XXA — Allergy, unspecified
- T88.7XXA — Unspecified adverse effect of drug or medicament
- T78.6XXA — Anaphylactic reaction due to other specified substances
- T80.52XA — Anaphylactic reaction due to serum
Immunodeficiency and Autoimmune Conditions
- D80.0 — Hereditary hypogammaglobulinemia
- D80.1 — Nonfamilial hypogammaglobulinemia
- D83.0 — Common variable immunodeficiency with predominant abnormalities of B-cell numbers/function
- D83.1 — Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
- D89.9 — Disorder involving the immune mechanism, unspecified
- D84.1 — Defects in the complement system
- D84.9 — Immunodeficiency, unspecified
- Z94.0 — Kidney transplant status
- Z94.1 — Heart transplant status
- Z94.2 — Lung transplant status
Eosinophilia and Mast Cell Activation
- D72.1 — Eosinophilia
- D89.40 — Mast cell activation disorder, unspecified
- D89.41 — Mast cell activation syndrome (MCAS)
- D89.42 — Secondary mast cell activation
- J33.9 — Nasal polyp, unspecified
- R76.0 — Raised antibody titer
- R76.8 — Other specified abnormal immunological findings
- D47.Z1 — Mast cell neoplasm of uncertain behavior
Asthma and Reactive Airway Conditions
- J45.20 — Mild intermittent asthma, uncomplicated
- J45.30 — Mild persistent asthma
- J45.40 — Moderate persistent asthma
- J45.50 — Severe persistent asthma
- J45.901 — Unspecified asthma with (acute) exacerbation
- J45.909 — Unspecified asthma, uncomplicated
- J98.01 — Acute bronchospasm
- J98.09 — Other diseases of bronchus
- R06.2 — Wheezing
Allergic Sinusitis and Nasal Disorders
- J32.9 — Chronic sinusitis, unspecified
- J01.90 — Acute sinusitis, unspecified
- J33.0 — Polyp of nasal cavity
- J34.89 — Other specified disorders of nose and nasal sinuses
- J34.2 — Deviated nasal septum
- J34.81 — Nasal mucositis
- J39.0 — Retropharyngeal and parapharyngeal abscess
Diagnostic Testing and Follow-Up
- Z01.89 — Encounter for other specified special examinations
- Z13.0 — Encounter for screening for blood disorders
- Z13.828 — Encounter for screening for other specified conditions
- Z71.89 — Other specified counseling
- Z02.89 — Other administrative examination
- Z00.00 — General medical exam without abnormal findings
- Z00.01 — General medical exam with abnormal findings
- Z09 — Follow-up examination after completed treatment
Vaccine Reactions and Immunization Concerns
- T88.0XXA — Infection following immunization, initial encounter
- T88.1XXA — Other complications following immunization, not elsewhere classified
- T88.9XXA — Unspecified complication following immunization
- Z28.82 — Immunization not carried out due to caregiver refusal
- Z28.21 — Immunization not carried out due to patient illness
- Z28.3 — Underimmunization status
- Z23 — Encounter for immunization
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